【行业】浮米每周专利快讯：2015年3月（二）

【行业】浮米每周专利快讯：2015年3月（二）2015-03-25[url=]浮米hfoom[/url]

1. WO 2015034271

标题: Novel antifungal pyridinylhydrazide derivatives

申请人: Daewoong Pharmaceutical Co., Ltd.

相关候选药物类型: 小分子药物

相关候选药物化学结构:

                               
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适应症:真菌感染

专利摘要: The present invention relates to novel pyridinylhydrazide derivatives and a method for manufacturing the same. The pyridinylhydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections. Additionally, the pyridinylhydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.

备注:嘧啶基酰肼类化合物可以用于治疗真菌感染，本发明的化合物对白念珠杆菌的MIC80 < 0.01 mcg/ml，对烟曲霉菌的MIC50 = 0.3 mcg/ml。

2. WO 2015034820

标题: Compounds useful as immunomodulators

申请人: 百时美施贵宝

相关候选药物类型: 小分子药物

相关候选药物化学结构:

                               
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适应症:癌症、病毒感染

专利摘要: Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.

备注:PD-L1抑制剂可用于治疗癌症和病毒感染。本发明的化合物对PD-1/PD-L1的IC50为0.006~0.1 mcM。

3. WO 2015033888

标题: Novel 2,6-diaminopyrimidine derivative

申请人: Carna Biosciences, Inc.

相关候选药物类型: 小分子药物

相关候选药物化学结构:

                               
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适应症:自身免疫疾病、炎症、淋巴瘤、癌症

专利摘要: [Problem] To provide a novel 2,6-diaminopyrimidine derivative. [Solution] A 2,6-diaminopyrimidine derivative represented by formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, R1 represents a lower alkyl group which may have a substituent, or an alkoxy group which may have a substituent; Ar represents an aryl group which may have a substituent, or a heteroaryl group which may have a substituent; each of Z1 and Z2 represents a carbon atom, or Z1 and/or Z2 represents a nitrogen atom; Q represents a structure selected from structures (a) and (b); R2 represents a lower alkyl group which may have a substituent, or a cycloalkyl group which may have a substituent; R3 represents a hydrogen atom or a halogen atom; Y represents a nitrogen atom or a carbon atom; and a double line composed of a dashed line and a solid line in structure (a) represents a double bond or a single bond.)

备注:BTK抑制剂可以治疗自身免疫疾病、炎症、淋巴瘤和癌症。本发明的化合物对BTK的IC50为2.1 nM。

4. WO 2015030057

标题: Novel morpholine derivative or salt thereof

申请人: FUJIFILM Corp.

相关候选药物类型: 小分子药物

相关候选药物化学结构:

                               
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适应症:癌症

专利摘要: A morpholine derivative represented by general formula [1A] or a salt thereof. In the formula, the ring A represents a ring represented by general formula [I] or the like; * represents a binding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other and independently represent a hydrogen atom or the like; R3, R4 and R5 are the same as or different from one another and independently represent a hydrogen atom, NRaRb or the like; and Ra and Rb independently represent a hydrogen atom, a C1-8 alkyl group which may have a substituent or the like.

备注:ATM激酶抑制剂可用于治疗癌症。本发明的化合物对ATM的IC50小于0.1 mcM。

(by 浮米网)

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